In article <t2kpt4$3mp8r$74@news.freedyn.de>
<governor.swill@gmail.com> wrote:
>
> It's a FAGGOT SPREAD DISEASE! Nothing will change that.
>

Specific sexual behaviors were linked to where monkeypox
symptoms showed up on the body of infected individuals,
researchers in Spain reported.

Proctitis, an inflammation in the lining of the rectum, was more
likely in individuals who reported anal receptive sex, while
nearly all of those who presented with ulcerative tonsillitis
reported oral receptive sex, found Oriol Mitj�, PhD, of
University Hospital Germans Trias i Pujol in Badalona, Spain,
and colleagues in a study published in The Lancet.

"Lesion swabs showed the highest viral loads, which, combined
with the history of sexual exposure and the distribution of
lesions, suggests close contact is probably the dominant
transmission route in the current outbreak," the group wrote.

The findings were consistent with a viral load more than three
orders of magnitude higher in lesion samples than in respiratory
samples.

"Strikingly higher viral loads in lesion swabs than in
pharyngeal swabs should be further investigated to guide the
decision on whether respiratory transmission is relevant and
respiratory isolation at home is necessary," the researchers
added.

Their study enrolled 181 human monkeypox virus-infected patients
from three sexual health clinics in Madrid and Barcelona. Of
these patients, 166 identified as gay, bisexual, or men who had
sex with men (MSM), and 15 identified as heterosexual men or
heterosexual women.

Investigators collected lesion, anal, and oropharynx swabs for
PCR testing and surveyed patients on specific sexual activities,
asking them to report on number of sexual partners and sexual
practices, including whether they practiced vaginal insertive
sex, anal insertive or receptive sex, and oral insertive or
receptive sex.

Proctitis was an absolute 31% more likely among MSM who reported
anal receptive sex than among other MSM (38% vs 7%, P<0.0001).
These patients also had a higher frequency of viral prodrome
than the group that did not report anal receptive sex (62% vs
28%, P<0.0001).

Of the 18 out of 19 patients presenting with ulcerative
tonsillitis who reported oral receptive sex, higher viral load
on the skin was found compared to throat swabs (mean cycle
threshold value 23 vs 32, P<0.0001).

"Our study strengthens the evidence for skin-to-skin contact
during sex as the dominant mechanism of transmission of
monkeypox, with important implications for disease control," the
authors wrote.

"Anorectal and genital epithelium routes exhibit the highest
probability of sexually transmitted infection acquisition
because they have a lower degree of keratinization and a higher
frequency of antigen-presenting cells such as macrophages and
dendritic cells," they noted.

In an accompanying commentary, Dimie Ogoina, MD, of the Niger
Delta Teaching Hospital in Bayelsa, Nigeria, and president of
the Nigerian Infectious Diseases Society, noted the findings
were similar to studies outside countries where human monkeypox
is endemic.

"There have been no previous reports of proctitis from countries
where monkeypox is endemic, but atypical presentations, such as
genital rash as the first symptom and lack of distinct febrile
prodrome, have been reported from Nigeria," Ogoina wrote.

Ogoina also pointed to a New England Journal of Medicine study
on monkeypox in a cohort of 16 countries that found the virus in
the seminal fluid in 29 of 32 tested samples. That study
reported complications such as conjunctival lesions, acute
kidney injury, and a self-limiting myocarditis, which were not
observed by the researchers in Spain.

Mitj� and co-authors noted that 32 individuals in their cohort
(18%) acquired monkeypox infection despite a smallpox
vaccination history, which "warrants further investigation to
better understand the protection provided by vaccination in the
context of the current outbreak."

Limitations of the study included no testing of other bodily
fluids such as blood and semen, "although it is still unclear
whether these bodily fluids contribute to monkeypox virus
transmission," Ogoina pointed out.

"The authors also did not evaluate longitudinal changes in cycle
threshold values that could have differential peaks at the
different lesion sites during the natural history of human
monkeypox," he added.

https://www.medpagetoday.com/infectiousdisease/generalinfectious
disease/100176